HPMC Polymers and Xanthan Gum Assisted Development and Characterization of Stavudine Extended Release Floating Tablets

Abstract: Objectives: Stavudine has a low half-life of 0.8-1.5 hr and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order enhance preserve the level stavudine for round clock, gastroretentive systems (floating low-density formulations that cause buoyancy on gastric fluid in stomach) may prove be advantageous releasing content from matrix tablet reservoirs several hours. Materials Methods: The current research endeavors towards formulating floating (F1-F9) employing rate modifying polymers such as HPMC K15M, xanthan gum K100M using multiple punch compression machine containing 9 mm diameter, flat-faced punches form 80 mg with batch size 100. drug-polymer compatibility was investigated through Fourier-Transformed Infrared Spectroscopy (FTIR) Differential Scanning Calorimetry (DSC). Results: were successfully fabricated. pre-compression characteristics (tapped density, bulk Hausner’s ratio, Carr’s index angle repose) well postcompression (appearance, hardness, dimension, content, friability, swelling index, weight variation, vitro release, buoyancy, accelerated stability release kinetics 90 days) comprehensively studied. Conclusion: This study will definitely open new milestones anti-retroviral pharmacotherapeutics upcoming future perspectives by enhancing extended-release attributes. Keywords: Stavudine, Floating, Tablet, Gastroretentive, Xanthan,